Timing,distribution,and microbiology of infectious complications after necrotizing pancreatitis

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World J Gastroenterol 2019 September 14; 25(34): 5162-5173DOI: 10.3748/wjg.v25.i34.5162ISSN 1007-9327 (print) ISSN 2219-2840 (online)ORIGINAL ARTICLE

Retrospective Study

Timing, distribution, and microbiology of infectious complications after necrotizing pancreatitis Jiong-Di Lu, Feng Cao, Yi-Xuan Ding, Yu-Duo Wu, Yu-Lin Guo, Fei Li ORCID number: Lu Jiong Di

(0000-0002-2494-9590); Cao Feng

(

0000-0001-7412-2455); Ding Yi Xuan (0000-0001-6752-9660); Wu Yu Duo (0000-0002-0407-1864); Guo Yu

Lin (0000-0003-3563-8998); Fei Li

(0000-00020532-9054).Author contributions: Lu JD is the first author; Cao F and Li F designed and performed the

research; Ding YX, Guo YL, and

Wu YD contributed the analytical

tools; Lu JD, Ding YX, and Guo YL

analyzed the data; Lu JD wrote the

manuscript; Cao F, Ding YX, and

Li F revised the manuscript; and all

authors read and approved the

final manuscript.Supported by the Beijing Municipal Science & Technology Commission, No.Z171100001017077; the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support, No. XMLX201404.Institutional review board statement: The study was reviewed and approved by the Xuanwu Hospital Institutional Review https://www.docsj.com/doc/209780999.html,rmed consent statement: The data of our study cohort was obtained retrospectively from the Xuanwu Hospital Database of Capital Medical University. Hence informed consent statement is unnecessary.Conflict-of-interest statement:None of the authors has a conflict of interest related to the

manuscript.

Jiong-Di Lu, Feng Cao, Yi-Xuan Ding, Yu-Lin Guo, Fei Li, Department of General Surgery,Xuanwu Hospital, Capital Medical University, Beijing 100053, China Yu-Duo Wu, Department of Cardiac Surgery, Beijing Anzhen Hospital Affiliated to Capital University of Medical Sciences, Beijing 100029, China Corresponding author: Fei Li, MD, PhD, Chief Doctor, Professor, Surgeon, Department of

General Surgery, Xuanwu Hospital of Capital Medical University, No. 45, Changchun Street,Xicheng District, Beijing 100053, China. feili36@https://www.docsj.com/doc/209780999.html, Telephone: +86-10-83198731

Fax: +86-10-83198868Abstract BACKGROUND Acute pancreatitis (AP) is a common acute abdominal disease worldwide, and its

incidence rate has increased annually. Approximately 20% of AP patients develop into necrotizing pancreatitis (NP), and 40% to 70% of NP patients have infectious complications, which usually indicate a worse prognosis. Infection is an important sign of complications in NP patients.AIM

To investigate the difference in infection time, infection site, and infectious strain in NP patients with infectious complications.METHODS

The clinical data of AP patients visiting the Department of General Surgery of Xuanwu Hospital of Capital Medical University from January 1, 2014 to December 31, 2018 were collected retrospectively. Enhanced computerized tomography or magnetic resonance imaging findings in patients with NP were included in the study. Statistical analysis of infectious bacteria, infection site, and infection time in NP patients with infectious complications was performed,because knowledge about pathogens and their antibiotic susceptibility patterns is essential for selecting an appropriate antibiotic. In addition, the factors that might influence the prognosis of patients were analyzed.RESULTS

In this study, 539 strains of pathogenic bacteria were isolated from 162 patients with NP infection, including 212 strains from pancreatic infections and 327strains from extrapancreatic infections. Gram-negative bacteria were the main infectious species, the most common of which were Escherichia coli and WJG https://https://www.docsj.com/doc/209780999.html, September 14, 2019Volume 25Issue 345162