非小细胞肺癌3～5个脑转移瘤优选调强放疗的可行性研究

非小细胞肺癌3～5个脑转移瘤优选调强放疗的可行性研究胡银祥;卢冰;韩蕾;甘家应;欧阳伟炜;苏胜发;洪卫;付和谊

【期刊名称】《中华放射肿瘤学杂志》

【年(卷),期】2012(021)004

【摘要】Objective This study evaluates the feasibility of intensity-modulated radiation therapy (IMRT) to treat patients with 1 -5 brain metastases from non-small cell lung cancer (NSCLC).Methods 30 IMRT patients with brain metastases for NSCLC studied retrospectively.Whole brain radiotherapy plus three-dimensional conformal radiotherapy (WBRT + 3DCRT) and WBRT plus stereotactic radiotherapy ( WBRT + SRT) plans were generated.Planning target volume ( PTV ) and organs at risk dose were measured and compared by dose volume histogram.Differences were analyzed in the three techniques by Wilcoxon Z -test.Results D99％of the shoulder ( D99％-D90％) from IMRT were higher than from WBRT +3DCRT and WBRT+SRT in all cases.From D15％of slope (D90％-D10％) to D5％of tail (D10％-D1％),IMRT were lower than WBRT + 3DCRT and WBRT + SRT ( Z =- 4.72,P =0.000 and Z =- 4.72,P =0.000).D10％and D5％of IMRT were (35.1 ±1.42) Gy and (37.7 ±2.91) Gy,WBRT +3DCRT were (36.5±2.86) Gy and ( 39.1 ± 3.56) Gy ;WBRT + SRT were (36.2 ± 2.57) Gy and ( 38.7 ± 3.67) Gy.IMRT vs WBRT+ 3DCRT and WBRT + SRT were significant ( Z=-3.18,-3.18,P=0.001,0.001 and Z=- 4.11,- 3.02,P =0.000,0.002) in 13